OBJECTIVE: To develop new therapeutic targets for astrocytoma and explore potential mechanisms regulating astrocytoma relapse. STUDY DESIGN: Expression of RRBP1, MMP9, and Ki-67 was investigated at the center and periphery of astrocytoma tissues. RESULTS: RRBP1 expression was higher in peripheral than in central astrocytoma tissues, although the difference was not statistically significant. RRBP1 expression was significantly correlated with that of proliferative marker Ki-67 and invasive marker MMP9. CONCLUSION: These results indicate that high RRBP1 expression may regulate astrocytoma proliferation and invasion. However, further investigation is needed to elucidate the underlying potential mechanisms. © Science Printers and Publishers, Inc.