Maackia amurensis lectin II aids prognosis in breast ductal carcinoma of the breast
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M.J.B.M. Barreto de Melo Rêgo
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Department of Medicine, Centro Universitário CESMAC, Maceio, AL, Brazil
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Biosciences Center, Universidade Federal de Pernambuco, Recife, PE, Brazil
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Immunopathology Laboratory, Universidade Federal de Pernambuco, Recife, PE, Brazil
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Department of Biochemistry, Universidade Federal de Pernambuco, Recife, PE, Brazil
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Department of Pathology and Forensic Medicine, Universidade de São Paulo, Sao Paulo, SP, Brazil
Abstract
Objective: To evaluate the correlation between the sialic acid linkages α2,3 and α2,6 with the prognostic factors in pure lesion of ductal carcinomas in situ and mixed lesion with invasive components through the use of Maackia amurensis II and Sambucus nigra lectins in tissue macroarray slides. Study Design: A total of 109 patients were evaluated: 47 with pure ductal carcinoma in situ (DCIS) lesions and 62 with DCIS plus invasive ductal carcinoma. Results: The lectin histochemistry showed that the α2,3 sialic acid inversely correlates with the hormonal status of estrogen receptor and progesterone receptor (p=0.015 and p=0.024, respectively) and is highly expressed in tumors > 5 cm (p=0.01) in pure DCIS, while in the mixed lesion was inversely correlated with epidermal growth factor receptor 2 expression. The α2,6 sialic acid presented no correlation with any of the prognostic factors investigated in both populations. Conclusion: The results showed a differential expression of α2,3 sialic acid among the prognostic factors, indicating its importance as a DCIS biomarker for poor prognostics and confirming the lectin histochemistry as a powerful tool in diagnosis. © Science Printers and Publishers, Inc.
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