Descriptive Comparative Anatomohistological Study of the Main Dissected Organs of Mus musculus and Rattus norvegicus for Experimental Model Research
1
Health Sciences Center, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Department of Statistics, Universidade Federal Fluminense, Niteroi, RJ, Brazil
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Histology and Embryology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Embryology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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the Collaborating Center for Reference and Research on Diphtheria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Department of Pathology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Abstract
OBJECTIVE: To establish a descriptive and comparative anatomohistological analysis of mice and rats.STUDY DESIGN: A total of 30 Mus musculus mice and 15 Rattus norvegicus rats were used. All animals were kept specific-pathogen-free and absent of surgical interventions that could cause anatomical and physiological changes.RESULTS: The study observed species-specific anatomohistological characteristics, which will serve as a basis to assist in choosing the most satisfactory research model. CONCLUSION: The evolution of knowledge in biological and medical areas are attributed to anatomical,physiological, and immunological studies in animals,contributing to the discovery of prophylactic measures and disease treatments that affect humans and animals. As mice and rats are the most used animals in experimental studies, the anatomical and histological differences between species should be carefully evaluated in order to better apply the study model and avoid unnecessary waste. (Anal Quant Cytopathol Histpathol 2021;43:90–106) © 2021 Science Printers and Publishers Inc.. All rights reserved.
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